A drug used for cancer therapy has shown promise in reversing kidney damage caused by systemic lupus erythematosus, according to a Yale-led study published April 8 in the journal Science Translational Medicine.
Positive Phase III Trial Results for Potential Lupus Nephritis Treatment
Kidney transplant improves survival rates in patients with Lupus Nephritis
Study Shows Gazyva® May Offer Potential New Treatment for Lupus Nephritis
The Lupus Research Alliance shared positive topline results from a Phase 2 clinical study of a potential new treatment for proliferative lupus nephritis, the most severe form of kidney damage caused by lupus. Genentech, a member of the Roche Group, reported that at one year their drug Gazyva® (obinutuzumab) helped more patients achieve a complete response to treatment when added to standard of care with either mycophenolate mofetil or mycophenolic acid plus corticosteroids than those receiving standard of care alone.
Lupus Treatments Can Be Tailored to Patient's Individual Cells
The kidneys of patients living with systemic lupus erythematosus (SLE) are often under assault, and not all those living with the disease will respond to standard treatment. A new report published in the journal Nature Immunology online May 20 shows how tissue samples from these patients can accurately predict those more likely than not to respond to therapy. SLE is a disease marked by the attack on joints, skin, and kidneys by the body's immune system..
Kidney transplant boosts survival in lupus nephritis
Patients with LN-ESRD have high mortality rates, Dr. April Jorge of Massachusetts General Hospital in Boston, MA, noted in an email to Reuters Health.
"We found that among nearly all such patients in the US who were waitlisted, renal transplant was associated with a significant survival benefit," she said. "This is an encouraging finding, and clinicians should consider early referral for renal transplantation for patients with LN-ESRD who may be candidates, as this can reduce mortality."
Recurrent lupus nephritis less frequent after kidney transplant
Lupus nephritis is recurring less frequently among patients with end-stage renal disease who undergo kidney transplant, possibly due to improved immunosuppression, according to data presented by Debendra N. Pattanaik, MBBS, MD, of the University of Tennessee Health Science Center.Lupus nephritis is recurring less frequently among patients with end-stage renal disease who undergo kidney transplant, possibly due to improved immunosuppression, according to data presented by Debendra N. Pattanaik, MBBS, MD, of the University of Tennessee Health Science Center.
