Higher prescribed doses of hydroxychloroquine (HCQ) may be associated with lower odds of thrombotic events in patients with systemic lupus erythematosus (SLE), according to study results presented at the 2019 The American College of Rheumatology/Association of Rheumatology Professionals (ACR/ARP) Annual Meeting, held November 8 to 13, 2019, in Atlanta, Georgia.
Investigators conducted a prospective cohort study of patients with SLE, and HCQ blood levels were ascertained at study visits by liquid chromatography-tandem mass spectrometry. Thromboses were defined as venous, including deep vein thrombosis/pulmonary embolism, or arterial, including stroke, myocardial infarction digital gangrene, or other arterial thrombosis. Patients were followed-up until index thrombotic event. Mean HCQ blood levels were calculated by averaging values obtained at all cohort visits before thrombosis.
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